10.25909/5d0b22d61cf97
Loretta Chin
Loretta
Chin
Camilla Dorian
Camilla
Dorian
Mark Hutchinson
Mark
Hutchinson
Sarah Robertson
Sarah
Robertson
Toll-like receptor-4 antagonist (+)-naloxone elicits sexually dimorphic attenuation of inflammation-induced fetal programming in mice. Supplemental Figure 1
The University of Adelaide
2019
pregnancy
fetal programming
metabolic disorder
reproductive immunology
inflammation
cytokines
TLR4
Foetal Development and Medicine
Immunology not elsewhere classified
Reproduction
2019-06-20 06:28:57
Figure
https://adelaide.figshare.com/articles/figure/Toll-like_receptor-4_antagonist_-naloxone_elicits_sexually_dimorphic_attenuation_of_TLR4-mediated_fetal_programming_in_mice_Supplemental_Figure_1/8298908
<div>Effect of (+)-naloxone on Tlr4 mRNA expression induced by LPS challenge in fetal, placental and uterine tissues. Pregnant C57Bl/6 mice were administered LPS (S. typhimurium, 20 ug/kg) or PBS IP on gd 16.5, followed by (+)-naloxone (60 mg/kg) or PBS IP, and 4 hours later, placenta and fetal membranes were recovered from two implantation sites. Relative expression of Tlr4 in placenta (A), fetal membrane (B), fetal brain (C), decidua (D) and myometrium (E) was determined by qPCR and normalised to Actb. Data are mean ± SEM relative gene expression of n=6-12 tissues from n=6 dams/group and were analysed by one-way ANOVA and post-hoc Sidak t-test. a,b,c Different letters indicate differences between groups, P < 0.05.</div><div><br></div>Supplemental Figure 1 from:<br><br>Toll-like receptor-4 antagonist (+)-naloxone elicits sexually dimorphic attenuation of inflammation-induced fetal programming in mice<br>Chin P-Y, Dorian C, Sharkey DJ, Hutchinson MR, Rice KC, Moldenhauer LM, Robertson SA.